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Testosterone replacement therapy was developed in 1960 by scientists at the Army Medical Research Institute of Infectious Diseases (AMRIID), who believed there was an increasing number of cases of hypogonadism in the military and sought to find a cure. They experimented on male cadets, and discovered that the high levels of androgens (found in testosterone) produced a change in the immune system that increased the rate of inflammation in the heart, lymph nodes and body fat of the men. Tests showed that the high levels of androgen produced a decrease in the enzyme that converts testosterone to estrogen, the hormone responsible for the change in the immune response. Men were given estrogen at doses that were at or below the safe blood level of 10 milligrams per 100 milliliters of blood, and blood levels of the hormone remained consistent for up to one year, fat bulking and cutting. Android kitkat 4.4.4
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