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Download citation file: Anabolic steroids, such as danazol, have been used for years in the treatment of myelodysplastic syndromes (MDS)and for weight loss. Such use is generally accepted and legal within the UK, and it is not uncommon for MDS patients to become anabolic steroid users. However, recent research shows that there is little evidence that daidzein or the related drug diazolidinedione are effective treatments for the disorder in adults. There are several potential side-effects of these products – including bone marrow suppression – which increases the potential for MDS patients to develop depression or suicidal thoughts. It is unlikely that the current use of danazol and of the related products is associated with these side effects.
Anabolic steroids (aka anabolic androgenic steroids): these are synthetic compounds derived from the human orchidotropin hormone testosterone. They function to increase androgen levels by increasing the protein-tyrosine leucine binding site (PSTB) in muscle cells (1).
In this article, we describe recent research into the efficacy of anabolic steroids for treating MDS in adults (2) and a recent review (3).
Anabolic steroids may be useful in treating MDS, as it is commonly associated with a poor response to the more traditional weight-loss therapy (i.e. diet and exercise). But the treatment does not have a universal, single effect, and often the response to treatment can be variable (4).
The current practice of treating MDS in anabolic steroid use is based mostly on the idea that people have low self-confidence because of their weight – hence the belief that anabolic steroids can improve self-confidence in obesity patients.
Evidence for their effectiveness has been accumulating recently but is still limited (5).
Evidence of safety
We have recently examined the use of anabolic steroids and danazol in the treatment of patients with a range of MDS. This study found that the drugs were safe, and could be used safely in the treatment of MDS.
We have also found that daidzein, which is the active ingredient of most anabolic androgenic steroid preparations, significantly improved measures of quality of life.
We are still evaluating new studies in an attempt to discover whether this effect can be replicated by using daidzein, a less commonly used but effective alternative to steroids.
Diet and weight loss
Diet is an important factor in the treatment of MDS, as people who lose weight are often more compliant with diet than normal weight patients (6).
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