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A study released in Nature Reviews Endocrinology discovered no clinical factor to recommend testosterone to males over 65 years of age with regular or reduced to typical testosterone degrees.

The study was led by Dr Martin T. Meeusen, a clinical psychologist with a PhD in genetics and a passion for medicine. “It is not so much the levels of testosterone that have made this study significant, it’s the amount of variation in the ranges,” says Meeusen, “It was a very large study.”

Meeusen and his team assessed testosterone levels in more than 3,000 men of various age groups and measured what they call the “normal” range, which includes the median and the maximum. Then, they compared them to testosterone levels in men over the age of 65. What they found surprised them: The majority of those older men had significantly elevated levels of testosterone, which they described as normal. By contrast, the average testosterone levels of men over 65 were roughly the same as those of their younger counterparts.

“The main finding is that the average levels among the older men (65+) are consistent with what we already know about men’s testosterone production in their early 60s,” says Meeusen. “When the average levels are so low, this could be a symptom, and not an indicator that something is causing it.”

In a recent article published in the journal Diabetes Care, Meeusen and colleagues wrote that there are several possible explanations for this phenomenon. One possibility is that older men, due to their testosterone production and elevated sex hormones, actually have less normal levels than younger men. Another possibility is that older men simply have worse health, but have a lower testosterone to estrogen ratio due to poor nutrition or environmental factors.

“This study helps to explain why testosterone levels in older men are still high, since it shows that lower testosterone levels are not a sign that people are in trouble,” says co-author Dr. Brian F. Brown, a urologist at the University of Washington in Seattle. Brown says testosterone levels in women are lower than in men, and has been related to age and obesity. “The next step is to continue investigating the relationship between testosterone levels and disease, both in older men and in women.” But, he says, “to get at this issue, a much longer study with lots of participants would be needed to get a conclusive answer.”

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